Category: Research

Dr. Alik Widge – Engineering Brain Circuits to Improve Mental Flexibility

Dr. Alik Widge – Engineering Brain Circuits to Improve Mental Flexibility Alik Widge research update
Alik Widge, MD, PhD Assistant Professor of Psychiatry at the University of Minnesota 2017 One Mind / Janssen Rising Star Translational Research Award in Memory of Jeffrey S. Nye M.D., Ph.D. Award winner   Rigid, inflexible behavior is a core impairment that cuts across mental illnesses, from the intrusive thoughts of obsessive-compulsive disorder (OCD) to [...]

Dr. Susanne Ahmari – Effective and Safer Treatments for Obsessive Compulsive Disorder

Dr. Susanne Ahmari – Effective and Safer Treatments for Obsessive Compulsive Disorder Susanne Ahmari OCD Research
Rising Star Award Research Update – Susanne Ahmari, MD, PhD  Associate Professor of Psychiatry at the University of Pittsburgh 2018 One Mind / Janssen Rising Star Translational Research Awardee Obsessive-Compulsive Disorder is a common, long-lasting anxiety disorder where the person has recurrent, persistent, intrusive thoughts or impulses (obsessions) and repetitive behaviors (compulsions) that he or [...]

Dr. Paul Jenkins – Identifying and Developing More Effective Treatments for Bipolar Disorder

Dr. Paul Jenkins – Identifying and Developing More Effective Treatments for Bipolar Disorder Paul Jenkins Bipolar Research image
Rising Star Award Research Update – Paul Jenkins, PhD  Assistant Professor of Pharmacology and Psychiatry at the University of Michigan 2018 One Mind Rising Star Bipolar Disorder Translational Research Award Bipolar Disorder is a serious mental illness that affects more than 6 million people in the United States. Notable for causing mood swings from mania [...]

Dr. Kate Fitzgerald – Reducing anxiety in preschool-aged children

Dr. Kate Fitzgerald – Reducing anxiety in preschool-aged children Kate Fitzgerald One Mind
Rising Star Award Research Update – Kate Fitzgerald,  Associate Professor of Psychiatry at the University of Michigan 2016 One Mind/Aim Sullivan Family Foundation Rising Star Award winner Childhood and adolescence is the core risk phase for the development of anxiety symptoms and syndromes. The fear of new experiences is common for young children, but for [...]

Dr. Erin Dunn – How Stress and Adversity Leads to Depression

Dr. Erin Dunn – How Stress and Adversity Leads to Depression Erin Dunn Research Update
Rising Star Award Research Update - Erin Dunn, ScD, MPH Assistant Professor of Psychiatry at Massachusetts General Hospital and Harvard Medical School 2018 One Mind Peter Chiarelli Rising Star Collaborative Research Award winner   Exposure to stress and adversity in childhood is a leading risk factor for depression. Experiencing such events as a death in [...]

Dr. Ming-Hu Han: Understanding Stress Resilience to Remedy Depression

Dr. Ming-Hu Han: Understanding Stress Resilience to Remedy Depression
Major depressive disorder (MDD) is a devastating disease that afflicts about 5% of the population. Stress is known to play a large role in causing major depressive episodes in people who are biologically susceptible. What is it about the brains of those 5% of people that makes them susceptible to depressive episodes when they are [...]

Dr. Lisa Monteggia: Reverse-Engineering the Rapid Antidepressant Effect of Ketamine

Dr. Lisa Monteggia: Reverse-Engineering the Rapid Antidepressant Effect of Ketamine
Antidepressant medications typically require a few weeks to start producing their therapeutic effects in patients.  The drug ketamine has recently been discovered to produce antidepressant effects much more quickly-within hours of the first dose. The advantages of this speedier response are obvious, especially for patients in suicidal crisis. Figuring out the molecular basis for this [...]

Understanding Genetic Risk Factors for Autism: Dr. Lauren Weiss

Understanding Genetic Risk Factors for Autism: Dr. Lauren Weiss Lauren Weiss Brain Scientist One Mind
"Autism is one of the most highly heritable and complex disorders known, but a genetic cause or risk factor can be identified in only about 10% of autism cases," says Lauren Weiss, Ph.D., One Mind sponsored Assistant Professor of Psychiatry at UCSF. "However, genome-wide association studies have begun to identify common and rare genetic variants [...]

Social Anxiety Susceptibility Linked to a Specific Brain Circuit and Genetic Variation

Social Anxiety Susceptibility Linked to a Specific Brain Circuit and Genetic Variation
Changes in social behavior are common in autism, schizophrenia, depression, anxiety, and a variety of other psychiatric disorders, but the neurobiological basis of these problems is not well understood. Recent research published in Molecular Psychiatry, provides a better understanding of these changes by identifying a neural circuit in the brain that when disrupted through a [...]

Predicting depression risk and treatment response through blood chemistry

Predicting depression risk and treatment response through blood chemistry Ian Maze Brain Scientist One Mind
Rising Star Award Research Update - Ian Maze, PhD Assistant Professor, Departments of Neuroscience and Pharmacological Sciences at Icahn School of Medicine at Mount Sinai 2017 Rising Star Early Diagnostics Basic Research Award winner   Major Depressive Disorder (MDD) afflicts over 300 million people worldwide, but current antidepressant medications work to relieve symptoms in only [...]