An estimated 15 million people are affected annually by traumatic brain injury and one out of every four people on this planet at some time will be affected by a psychiatric illness.

These conditions are the number one cause of disability worldwide, and are estimated to surpass many diseases as the major cause of death by 2020. In parallel, it is estimated that nearly 1 million people worldwide will end their lives by suicide, with 90% of these people having a psychiatric condition.

Untreated brain illness or injury is a life-altering condition that significantly debilitates individuals, their friends and families, and the surrounding economy. The global economic burden from mental illness alone is estimated at nearly $2.5 trillion per year, projected to rise to $6 trillion by 2030.

In addition to these staggering statistics, there are hurdles within the current research landscape that slow the pace of biomedical brain research.

Muddled in structurally siloed organizations that focus more on their success than that of the patient, researchers are incentivized to publish papers rather than to work together to accelerate the pace of cures. In a truly patient-focused environment, the need for researchers to collaborate is paramount, as is the facilitation of open-science data sharing.

The research to clinical practice environment is similarly hindered. Recent estimates indicate that it takes an average of 17 years for medical discoveries to be applied in community settings – the place where they can help patients who struggle. This delay is unacceptable and must be accelerated.

Overcoming these limitations is what drives our efforts.

With a focus on fostering paradigm-shifting scientific research and collaborations, our work is changing the culture within the current research landscape to radically accelerate cures for brain illnesses and injuries now.

With funds raised by donors like you, we are already achieving significant progress towards brain related cures.

3-Disability

Learn more about the following brain conditions:

What is Traumatic Brain Injury (TBI)?

According to the CDC, each year approximately 2.5 million people sustained a traumatic brain injury, either as an isolated injury or along with other injuries. Within this, each year approximately 282,000 people are hospitalized and 56,000 deaths occur due to TBI’s. In total, more than 5.3 million Americans live with the disabilities caused by TBI.

These numbers are projected to grow with the World Health Organization projecting that by 2020, TBI will become the leading cause of neurological disability across all age groups.

Learn about the signs, symptoms and causes of TBI

What Are We Doing?

Effective treatment of TBI represents a major unmet need in public health. Knowing the enormous negative impact TBI’s have on the world, both in volumes and costs, One Mind is focused on accelerating the pace of research so to help achieve successful clinical trials and treatments for TBI.

One Mind financially supports a number of large-scale, collaboratively focused multicenter research studies, including the NINDS-funded Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study and the Department of Defense funded TBI Endpoints Development (TED) Initiative study.

Focusing on ‘funding the gaps’ within each study, One Mind’s financial and collaborative support has resulted in patient study retention rates that are two to three times higher than the norm, thereby leveraging the NIH and DoD funding at a similar rate.

Learn more about our work in support of TBI

What is Post-Traumatic Stress?

Post traumatic stress affects about 7.7 million American adults, age 18 or over, annually. 70% of adults in the U.S. have experienced some type of traumatic event at least once in their lives, with close to 20% of these people going on to develop PTS. An estimated 8% of Americans – 24.4 million – will experience PTS at some point in their lives.

Almost 50% of all outpatient mental health patients have PTS. 11-20% of Veterans of the Iraq and Afghanistan Wars do too. Among the people who are victims of specific traumatic experiences such as rape, child abuse and violent assaults, the rate of PTS is 60-80%.

Learn about the signs, symptoms and causes of post-traumatic stress

What Are We Doing?

Knowing that the current methods of diagnosing post-traumatic stress as well as the understanding of the biological underpinnings that cause the illness remain limited, One Mind is actively supporting the recently launched AURORA study on trauma.

The AURORA study is a major national research initiative led by researchers at the University of North Carolina and Harvard that will collect and analyze data from 5,000 trauma patients over a 5-year span. The goals of the AURORA study are to deliver tools for clinicians to make informed decisions about patients’ risk and care after a traumatic experience and to identify new intervention targets that will give rise to mechanism-informed treatments based on individual needs.

One Mind has pledged to raise $7.9 million over the next 5-years to give to the AURORA study to fill the gaps in the National Institute of Mental Health funding the study has received. Learn more about the AURORA study and the support we provide.

Learn more about our work in support of post-traumatic stress

What is Depression?

Depression – an umbrella term that includes disorders such as major depression, seasonal affective disorder, and persistent depressive disorder– can manifest in anyone. Sufferers often feel run down, hopeless, and alone.

If you suspect someone you love may be battling with depression, there are various signs you can watch for. You may notice these symptoms after childbirth, following the loss of someone close, during the winter months, or at random.

Learn about the signs, symptoms and causes of depression

What Are We Doing?

With support from our Rising Star Awards program, unprecedented strategies are being implemented to help major depression patients.

Toward developing individualized diagnosis and treatment, Dr. Conor Liston has neuroimaged 1000 patients to discover four distinct depression subtypes.

Dr. Kafui Dzirasa has developed a prototype “brain pacemaker” that restores stress resilience in mouse models.

Dr. Mary Kay Lobo is developing a genetic target for future precision depression medications.

Learn more about our work in support of depression

What is Schizophrenia?

Schizophrenia is a serious brain disorder characterized by the combined presence of certain symptoms or the experience of being out of touch with reality and lack of interest in the outside world.

If you’re concerned that someone you know might be developing schizophrenia, you can look for signs in their physical appearance, content of expression, and their ongoing behavior.

Learn about the signs, symptoms and causes of schizophrenia

What Are We Doing?

With support from One Mind and our partners, researchers are pioneering innovative treatments to help schizophrenia patients. 

Dr. Carrie Bearden and the North American Prodrome Longitudinal Study are discovering the means to prevent psychosis in its earliest stages.

To precisely target treatments, Dr. Philip Corlett’s neurocognitive research is revealing why psychosis debilitates.

Dr. Devanand Manoli aims to apply neurobiological discoveries to restore schizophrenia patients’ abilities to build healthy relationships.

Learn more about our work in support of schizophrenia

What is Bipolar Disorder?

Also known as manic-depressive illness, Bipolar Disorder is a brain disorder that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Without proper treatment, people with bipolar disorder may develop severe mania or depression.
If you suspect that someone you know might be bipolar, there are various signs to watch for. Treatment exists and can aid even those with the most severe forms of bipolar disorder.

What Are We Doing?

With support from our Rising Star Awards program, cutting-edge research is being done to help bipolar disorder patients.

Dr. Jean-Martin Beaulieu’s research is revealing molecular mechanisms to target for safer alternatives to current medications.

Dr. Colleen McClung is discovering precise gene targets to develop treatments to stabilize mania more effectively.

Dr. Jun Li’s identification of bipolar disorder’s genetic roots is opening doors to novel treatment development.

Learn more about our work in support of bipolar disorder