Dr. Herman Wolosker

Dr. Wolosker’s lab has transformed understanding of NMDA receptor signaling through D-serine biology, with therapeutic implications for neurodegenerative diseases.

Dr. Herman Wolosker is an Associate Professor of Biochemistry at the Technion–Israel Institute of Technology, internationally recognized for his pioneering work on D-serine, a critical co-agonist of NMDA receptors involved in synaptic plasticity, learning, and memory. His lab discovered that D-serine is produced in the brain by serine racemase and that its absence disrupts NMDA receptor signaling. Dr. Wolosker’s current research explores D-serine’s role in neurotoxicity and its implications for neurodegenerative diseases, including Alzheimer’s, Huntington’s, and ALS, with the goal of developing serine racemase inhibitors as potential neuroprotective therapies.