SCHIZOPHRENIA: 

Schizophrenia is a relatively uncommon disease, affecting about 1% of the world’s population. However, because of its symptoms, schizophrenia can be quite chronic and debilitating. Globally, approximately 1.5 million people will be diagnosed with schizophrenia each year.

Most often, new cases of schizophrenia occur in the teen years of adolescence, reaching a peak of vulnerability between the ages of 16 and 25 years. The full onset of schizophrenia is normally preceded by a prodromal period where the individual experiences odd behaviors such as restlessness, hallucinations and anxiety. During the prodromal period, the behaviors and thoughts generally present gradually, but not yet with their fullest force. It is common for the individual to notice the changes a few months before anyone else visibly recognizes the differences in behavior.

Common symptoms of schizophrenia include hallucinations, delusions and thought disorder, and can include lowered expression of emotions, reduced motivation, difficulty in relationships and cognitive impairment. If left untreated, the symptoms of schizophrenia can expand and present more persistently later in life.

Approximately half of individuals with schizophrenia have co-occurring mental and/or behavioral health disorders.

As per the focus of our ASPIRe program, our personal experiences, and the research advancements being made by our schizophrenia focused Rising Star Awardees, One Mind firmly believes that early interventions can significantly improve the course of schizophrenia.

Through our One Mind Rising Star Awards grant program and other funding support channels, One Mind has supported the following scientists in their important and influential schizophrenia focused research:

 

Eva Anton, Ph.D.
Demonstrating the NRG1 Gene as an Interneuron Migration Governor
Professor of Cell and Molecular Physiology
University of North Carolina
2006 Rising Star Awardee
Schahram Akbarian, M.D., Ph.D.
Discovering the Workings of the Epigenome.
Professor of Psychiatry and Neuroscience
Icahn School of Medicine at Mount Sinai
2008 Rising Star Awardee
Carrie Bearden, Ph.D.
Evidence supporting biomarkers for oncoming psychosis
Professor, Psychiatry and Biobehavioral Sciences
University of California, Los Angeles
Linda Brzustowicz, M.D.
Identifying Schizophrenia Gene Interaction and Expression
Professor of Genetics
Rutgers University
2005 Rising Star Awardee
Philip Corlett, Ph.D.
Potassium Channels and Prediction Error: Targeting Schizophrenia with Retigabine
Associate Professor of Psychiatry
Yale University
2013 Rising Star Awardee
Jennifer M. Coughlin, M.D.
Transdiagnostic Imaging of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
Associate Professor of Psychiatry and Behavioral Sciences
John Hopkins University
2019 Rising Star Awardee
Joshua Gordon, M.D., Ph.D.
Investigating the Circuit Basis for Psychiatric Diseases
Director
National Institute of Mental Health
2010 Rising Star Awardee
Devanand Manoli, M.D., Ph.D.
Assistant Professor of Psychiatry
University of California, San Francisco
Andrew Pieper, M.D., Ph.D.
Developing Potential Therapies for Schizophrenia and Neurodegenerative Diseases
Director of the Alzheimer Drug Discovery Foundation-Harrington Scholar Program
Cleveland Medical Center
2009 Rising Star Awardee
Akira Sawa, M.D., Ph.D.
Understanding Why DISC1 is a Schizophrenia Risk Gene
Director and Endowed Chair, John Hopkins Schizophrenia Center, John Hopkins University School of Medicine and Bloomberg School of Public Health
John Hopkins University
2007 Rising Star Awardee
Carl Sellgren Majkowitz, M.D., Ph.D.
Targeting the Rewiring of the Connectome in Adolescence to Prevent Schizophrenia
Assistant Professor of Psychology and Pharmacology
Karolinska Institutet
2019 Rising Star Awardee
Vikaas Sohal, M.D., Ph.D.
Abnormalities in the brain's structure and activity may lead to symptoms of schizophrenia and autism
Assistant Professor of Psychiatry
University of California, San Francisco
Hongjun Song, Ph.D.
Understanding a Schizophrenia Susceptibility Gene's Effect on Neural Growth
Professor of Neuroscience
University of Pennsylvania
2009 Rising Star Awardee
Sophia Vinogradov, M.D.
New Tools to Improve Brain Functioning in Psychiatric Illness
Professor and Head, Department of Pscyhiatry
University of Minnesota
Susan Voglmaier, M.D., Ph.D.
Associate Professor of Psychiatry
University of California, San Francisco
Alik Widge, M.D., Ph.D.
Reverse Translational Circuit Dissection and Remediation of Mental Inflexibility
Assistant Professor of Psychiatry
University of Minnesota
2017 Rising Star Awardee
Herman Wolosker, M.D., Ph.D.
Rebalancing a Novel Neurotransmitter to Treat Schizophrenia
Professor of Biochemistry
Technion Institute (Israel)
2010 Rising Star Awardee