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One Mind Rising Star Awards

One Mind Rising Star Awards

The One Mind Rising Star Awards identify and fund pivotal, innovative research on the causes of and cures for brain disorders by supporting the most promising emerging leaders in the field of neuropsychiatry. Each Rising Star Research Award winner will receive $300,000 from One Mind over a three year-period to fund research for their studies, catalyzing innovations not yet supported by the federal government while encouraging collaboration and data sharing.

2020 Award Application Information

NEW APPLICATION DUE DATE IS MAY 31, 2020

One Mind, in collaboration with Janssen Research & Development and the Baszucki Brain Research Fund, is offering up to 2 Rising Star Research Awards in 2020. The goal of the Rising Star Research Awards is to recognize and fund promising, early career investigators through a competitive grants process to accelerate research on neuropsychiatric disorders. One Mind, in collaboration with Inscopix, is also offering up to two supplemental technology grants, each in support of one Rising Star Research Award. We are also pleased to announce up to 10 Bipolar Research Awards thanks to additional support from the Baszucki Brain Research Fund.

The application for the 2020 Rising Star Awards is now open. Please read the information below or download and review the 2020 Rising Star Award Application. Additional information is also available on our Rising Star Awards FAQ page. In consideration to the challenges created by the COVID-19 pandemic, we are extending the due date for the application submission. All applications must now be submitted to One Mind on or before May 31, 2020 (rather than the original May 13 date).

  • The project period for the awards is 3 years.
  • The total funding for each Rising Star Research Award is $300,000, of which $100,000 will be distributed annually. Continuation of the awards for the second and third years of the research are dependent upon review of an annual progress report by the Chair of the One Mind Scientific Advisory Board and the One Mind Director of Science and Technology.
  • Indirect costs are limited to a maximum of 10% and will be taken from the direct costs.
  • To qualify as an early career investigator, candidates should be within 10 years of their initial independent appointment as an assistant professor for academic institutions or equivalent positions for industry or other non-academic positions. Note that postdoctoral fellows are ineligible.
  • Candidates should have demonstrated productivity and innovation in a scientific field that can be applied to the study of neuropsychiatric disorders, such as anxiety, addiction, bipolar disorder, depression, posttraumatic stress, schizophrenia, traumatic brain injury, suicidality, and other serious psychiatric illnesses.
  • Awardees will be invited to attend One Mind’s 26th Music Festival for Brain Health activities on September 11 – 12, 2020 and give a presentation about their award-winning research plans at the Music Festival’s Scientific Symposium.
  • The proposal should not overlap with existing funding.
  • Applicants may apply for the One Mind/Inscopix Technology Grant only as a supplement to a Rising Star Award proposal. Applicants cannot solely apply to the Technology Grant.

One Mind Rising Star Research Awards:

Proposals for studies on any of a wide range of neuropsychiatric conditions are in scope (see face sheet on the application for examples), with studies focusing on bipolar disorder of special interest, including applications that would advance therapeutics for bipolar disorder, ranging from biomarkers to promising therapeutic modalities including neurostimulation. Examples of relevant research on neuropsychiatric and/or neurotraumatic disorders include, but are not limited to studies that aim to:

  • Discover biological mechanisms and therapeutic targets;
  • Develop new or refine existing models and research tools;
  • Identify or validate biomarkers;
  • Evaluate the effectiveness of therapies, including pharmaceuticals, electroceuticals, digital therapies or cognitive and behavioral health interventions to prevent the onset or promote recovery of neuropsychiatric disorders using pre-clinical or computational models or with pilot clinical studies;
  • Characterize similarities and differences between two or more neuropsychiatric or neurotraumatic disorders to advance personalized medicine;
  • Improve our understanding of how comorbid conditions, such as cancer and diabetes, as well as other neurological and non-neurological disorders, interact with neuropsychiatric disorders and impact diagnosis, prognosis and treatments;
  • Promote or restore brain health by conducting bi-directional and/or iterative translational research using existing clinical data or new data from small pilot clinical studies, in combination with relevant pre-clinical or computational models; or
  • Advance digital health, telehealth or other innovative approaches to increasing access to mental health care.

To advance knowledge and grow the community of researchers, up to 10 proposals on bipolar disorder will also be considered to a one-time award of $10,000. The funds can be applied toward travel to the One Mind Music Festival or to other scientific meetings, to pilot studies, or to any other costs relevant to advancing research on bipolar disorder. Awards will be given to highly meritorious, runner up applications to the Rising Star Awards that have direct relevance to bipolar disorder. No indirect costs are allowed.

Applicants whose proposals can be enhanced by optical methods to investigate links between neural circuit/ensemble dynamics and disease phenotypes are within scope and encouraged to apply for this supplemental award from Inscopix. Proposals might include, but are not limited to:

  • Signal analysis in health vs. disease, and/or how circuit/ensemble signatures change and evolve during disease progression an in therapeutic intervention paradigms.
  • Studies that use established or new rodent models of neuropsychiatric disorders to extract key characteristics of the pathophysiology in a cell type-and/or circuit-specific manner.
  • Investigations into the causal role of disease circuit/ensemble dynamics identified with nVoke/nVista and potentially in conjunction with other methods such as pharmacology, chemogenetics, electrophysiology and cell ablation.

Each Technology Grant includes:

  • 1 state-of-the-art nVoke miniature microscope system from Inscopix for integrated in vivo Ca+2 imaging and optogenetics (simultaneous or sequential) in the brains of freely behaving mice. Applicants can request an nVista system in lieu of nVoke should their proposal require only Ca+2 imaging either in the mouse brain and/or in the rat neocortex and hippocampus.
  • Full scientific support including a dedicated Field Scientific Consultant for the duration of the project to provide on-site training and guidance to the awardees, from experimental design to data analysis. The award will also provide an opportunity to engage with Inscopix’s transdisciplinary team of neuroscientists, data scientists, and engineers.
  • Full technical support including iCare (no questions asked repair and replacement service, for the duration of the award).

For complete details and scope parameters for the Inscopix Technology Supplement Grant, please read the 2020 Rising Star Award RFP.

Past Rising Star Award Winners

In 2019, in collaboration with Janssen Research & Development, Otsuka Pharmaceutical, Kaiser Permanente, the Gifford Foundation and Bettina Bryant, One Mind awarded five Rising Star Awards:

Stephan Lammel Research

STEPHAN LAMMEL, PH.D.

2019 One Mind – Janssen Rising Star Translational Research Award

LAURA LEWIS, PH.D.

2019 One Mind – Bettina Bryant Rising Star Depression Research Award

Jennifer M. Coughlin Research

JENNIFER M. COUGHLIN, M.D.

2019 One Mind – Gifford Foundation Rising Star Schizophrenia Research Award

Dr. Lammel is Assistant Professor of Neurobiology at the University of California, Berkeley. His research focuses on depression as well as addiction, including substance use disorder and severe eating disorders, which represent a major threat to public health and an enormous socioeconomic burden. Dr. Lammel’s study, entitled “Decoding multiple dimensions of dopamine signaling for impulse control” aims to provide a detailed understanding of how different brain circuits interact to mediate behavioral suppression (or fail to do so).

Dr. Lewis is Assistant Professor in the Department of Biomedical Engineering at Boston University. Her study, “Identifying intersecting network dynamics underlying sleep and mood in depression” focuses on the unexpected observation that sleep deprivation rapidly improves symptoms in roughly 50% of individuals with depression. Why this happens is unknown, and her research uses newly developed brain imaging techniques to understand the biological interactions between sleep and depression.

Dr. Coughlin is Associate Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University. Her study “Transdiagnostic imaging of the α7 nicotinic acetylcholine receptor in recent-onset psychosis” builds upon post-mortem studies that demonstrated alterations in binding to the receptor in selected regions of the brain.  She aims to use sophisticated imaging tools to further investigate these alterations and ultimately enable more targeted and effective treatments for schizophrenia and other psychotic disorders.

Denise Cai Research

DENISE CAI, PH.D.

2019 One Mind – Otsuka Rising Star Research Award

Carl Sellgren Majkowitz Research

CARL SELLGREN, M.D, PH.D.

2019 One Mind – Kaiser Permanente Rising Star Research Award

Dr. Cai is Assistant Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. Her research, entitled “Temporal memory-linking: a circuit mechanism of PTSD” investigates how memories of traumatic events can be linked across time and trigger a fearful response in a safe environment. Using state of the art genetic and brain imaging tools, her experiments will provide critical insight into how we integrate current and past experiences to make predictions about the future.

Dr. Sellgren Majkowitz is Assistant Professor at the Department of Physiology and Pharmacology at Karolinska Institutet in Sweden. His study, entitled “Targeting the rewiring of the connectome in adolescence to prevent schizophrenia” addresses key gaps in knowledge around the hypothesis that excessive synaptic pruning during brain development contributes to the observed reduction in synapse density in schizophrenia.

Click the Years to See Past Awardees: 

Dr. Denise Cai 2019 One Mind / Otsuka Rising Star Research Award. Temporal memory-linking: a circuit mechanism of PTSD. Icahn School of Medicine at Mount Sinai.

Dr. Jennifer M. Coughlin – 2019 One Mind / Gifford Foundation Rising Star Schizophrenia Research Award. Transdiagnostic imaging of the α7 nicotinic acetylcholine receptor in recent-onset psychosis. Johns Hopkins University.

Dr. Stephan Lammel – 2019 One Mind / Janssen Rising Star Translational Research Award. Decoding multiple dimensions of dopamine signaling for impulse control. University of California, Berkeley.

Dr. Laura Lewis – 2019 One Mind / Bettina Bryant Rising Star Depression Research Award. Identifying intersecting network dynamics underlying sleep and mood in depression. Boston University.

Dr. Carl Sellgren-Majkowitz – 2019 One Mind / Kaiser Permanente Rising Star Collaborative Research Award. Targeting the rewiring of the connectome in adolescence to prevent schizophrenia. Karolinska Institutet.

Dr. Susanne Ahmari 2018 One Mind / Janssen Rising Star Translational Research Award in Honor of the Late Jeffrey S. Nye, M.D., Ph.D..identify novel molecular targets for OCD. University of Pittsburgh.

Dr. Paul Jenkins – 2018 One Mind Rising Star Bipolar Disorder Translational Research Award. Therapeutic Modulation of ANK3 Dependent GABAergic Circuitry. University of Michigan.

Dr. Erin Dunn – 2018 One Mind Peter Chiarelli Rising Star Collaborative Research Award. Understanding why childhood stress is a major risk factor for depression in adolescents and young adults. Massachusetts General Hospital and Harvard Medical School.

Dr. Alik S. Widge 2017 One Mind / Janssen Rising Star Translational Research Award in Memory of Jeffrey S. Nye M.D., Ph.D.. Engineering Brain Circuits to Improve Mental Flexibility. University of Minnesota.

Dr. Ian Maze – 2017 Rising Star Early Diagnostics Basic Research Award. Predicting depression risk and treatment response through blood chemistry. Icahn School of Medicine at Mount Sinai.

Dr. Kate Fitzgerald 2016 One Mind / AIM for Mental Health Rising Star Research Award. Effortful control of training: a brain-targeted intervention for clinically anxious preschoolers. University of Michigan.

Dr. Mazen Kheirbek – 2016 One Mind / Janssen Rising Star Translational Research Award. Illuminating Circuit Based Targets for Treatment of Depression. University of California, San Francisco.

Dr. Mary Kay Lobo – 2016 One Mind / Janssen Rising Star Translational Research Award. Stabilizing Neuronal Architecture for Depression Therapeutics. University of Maryland School of Medicine.

Dr. Katie McLaughlin2015 One Mind / AIM Rising Star Award. Understanding How Stress Causes Anxiety and Depression in Youth. Harvard University.

Dr. Conor Liston – 2015 Janssen / One Mind Rising Star Translational Research Award. Neurobiologically Distinguishing Depression Subtypes. Weill Cornell Medical College.

Dr. Jean-Martin Beaulieu – 2014 One Mind / Johnson & Johnson Rising Star Translational Research Award. Developing Potentially Safer Bipolar Disorder Treatments. University of Toronto.

Dr. Stephanie Dulawa – 2014 One Mind Rising Star Depression Award in Memory of George Largay. Developing Faster-Onset Antidepressants. University of California, San Diego.

Dr. Philip Corlett – 2013 Janssen / One Mind Rising Star Translational Research Award. Potassium Channels and Prediction Error: Targeting Schizophrenia with Retigabine. Yale University.

Dr. Kafui Dzirasa – 2013 Janssen / One Mind Rising Star Translational Research Award. Closed Loop Actuators to Repair Brain Circuit Dysfunction. Duke University.

Dr. Scott Russo – 2012 Johnson & Johnson / One Mind Rising Star Translational Research Award. Investigating the Anti-Depressant Efficacy of Anti-Inflammatory Medications. Mount Sinai School of Medicine.

Dr. Colleen McClung – 2012 Johnson & Johnson / One Mind Rising Star Translational Research Award. Investigating Specific HDAC Gene Inhibition as a Novel Bipolar Disorder Treatment. University of Pittsburgh School of Medicine.

Dr. Ming-Hu Han – 2011 Johnson & Johnson / IMHRO Rising Star Translational Research Award. Understanding Stress Resilience to Remedy Depression. Mount Sinai School of Medicine.

Dr. Jun Li – 2011 Johnson & Johnson / One Mind Rising Star Translational Research Award. Seeking Out High-Risk Bipolar Disorder Candidate Genes. University of Michigan.

Dr. Lisa Monteggia – 2011 One Mind Rising Star Basic Research Award. Reverse-Engineering the Rapid Antidepressant Effect of Ketamine. Vanderbilt.

Dr. Joshua Gordon – 2010 One Mind Rising Star Award. Investigating the Circuit Basis for Psychiatric Diseases. Columbia University.

Dr. Herman Wolosker – 2010 One Mind Rising Star Award. Rebalancing a Novel Neurotransmitter to Treat Schizophrenia. Technion Institute, Israel.

Dr. Olivier Berton – 2010 One Mind Rising Star Award. Evaluating How to Use Stress-Governing Proteins to Diagnose, Treat or Prevent Affective Disorders. University of Pennsylvania School of Medicine.

Dr. Andrew Pieper – 2009 One Mind Rising Star Award. Developing Potential Therapies for Schizophrenia and Neurodegenerative Diseases. University of Iowa.

Dr. Francis Lee – 2009 One Mind Rising Star Award. Investigating the Role of a Growth Factor Deficiency in Affective Disorders. Weill Cornell Medical College.

Dr. Hongjun Song – 2009 One Mind Rising Star Award. Understanding a Schizophrenia Susceptibility Gene’s Effect on Neural Growth. Johns Hopkins University School of Medicine.

Dr. Schahram Akbarian – 2008 Staglin Music Festival / NARSAD Rising Star Award. Discovering the Workings of the Epigenome. University of Massachusetts Medical School.

Dr. Akira Sawa – 2007 Staglin Music Festival / NARSAD Rising Star Award. Understanding Why DISC1 is a Schizophrenia Risk Gene – And What to Do About It. Johns Hopkins University School of Medicine.

Dr. Eva Anton – 2006 Staglin Music Festival / NARSAD Rising Star Award. Demonstrating the NRG1 Gene as an Interneuron Migration Governor. University of North Carolina.

Dr. Linda Brzustowicz – 2005 Staglin Music Festival / NARSAD Rising Star Award. Identifying Schizophrenia Gene Interaction and Expression. Rutgers University.

See Geographically Where the Rising Star Awardees Are From:

Click the map below to see where each of the past Rising Star Award winners are from. The interactive map lists each awardee’s affiliated university, the year they won their award and the focus of their award-supported research.

Read about past Rising Star Awardees and other One Mind funded researchers on our Research Updates page.

For more information on the Rising Star Awards, please contact us.

Rising Star Awards Video

Why One Mind Support Matters

One Mind launched the Rising Star Awards program in 2005 under the fundamental principle that cutting edge, high risk research would allow us to find the breakthroughs to accelerate cures for the neuropsychiatric mental health disorders that affect 1 in 4 people worldwide. Knowing that 90% of these disorders are treatable, we wanted to create a highly impactful grant award that enables the researcher to think outside of the box and pursue research that might not otherwise be funded through federal organizations.

Since 2005, One Mind has awarded 34 awards to some of the best and brightest early career brain scientists, who since receiving their awards, have gone on to make a significant impact both in the research they have done and in the brain health community as a whole. Such awardees include 2010 Rising Star Award winner, Dr. Joshua Gordon who now serves as the Director of the National Institute of Mental Health.

At $250,000 per award, distributed over a 3-year period, the One Mind Rising Star Awards provide a dollar amount significant enough to truly support the research being done. The awards also provide early-career recognition that helps attract significant follow-on funding.

Kafui Dzirasa Research Testimonial