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About ASPIRe

Serious Psychiatric Illness is a major unmet health need. Often referred to as serious mental illness, SPIs include schizophrenia, bipolar disorder, major depressive disorder, and other psychiatric conditions that substantially interfere with major life activities. The impact on the individual and on society is especially large because 75% emerge in youth between the ages of 10 and 24 years. Ultimately, 7.5% of youth between the ages of 18 – 25 years and 20% of adults are affected.

There are no cures for SPI, but it can be effectively managed with pharmacological and psychosocial interventions. The rates of remission and recovery are difficult to capture, but the best estimates suggest recovery rates of approximately 25% for bipolar disorder and schizophrenia and 65% for major depressive disorder. A large nationwide survey conducted in 2014 and 2015 also found that 70% of individuals in the USA did not receive any care. We can and must do better.

Similar to most diseases, prevention and early intervention are key to better outcomes, which is what the One Mind Accelerating Serious Psychiatric Illness Recovery (ASPIRe) initiative aims to achieve.

Join the ASPIRe community by taking the ASPIRe Pledge.


100% access to effective, personalized care for individuals at risk for or living with serious psychiatric illness by 2040

75% recovery rate for individuals with serious psychiatric illness by 2040

Estimated Savings with CSC Treatment

Healing the lives of those with SPI

Many genetic, environmental and social factors play a role in the development and progression of serious psychiatric illness, and no single organization can address them all. Advances in care require multiple stakeholders, but they often work in silos. The result is that translating knowledge from research into something useful for people often takes years or even decades.

To accelerate the process, the ASPIRe initiative is developing a patient-centered model that starts with this question: What is needed to change the trajectory for individuals with serious psychiatric illness from one of despair and disability to one of hope and recovery?

We identified 5 essential needs: access to knowledge, early detection and intervention, access to effective care, better diagnostics and treatments, and implementation and evaluation in real world settings.

Aspire Roadmap to Recovery graphic


ASPIRe’s projects are a collaborative effort between a wide range of organizations working to support those with SPI.
Poprtrait of Andrew Echeguren

If it were not for early intervention in my psychosis, I do not believe I would be here today to tell my story.

Andrew Echeguren

Brain Health Advocate