Major depression is one of the most common mental disorders, affecting more than 264 million people worldwide.1 Although it is common for people to have short-term mood fluctuations, major depression with moderate to severe intensity can become a serious life altering condition. The burden of depression is on the rise.

Depression does not have one single cause but several biological, psychological and environmental risk factors. For youth and teens, depression is a risk factor for developing other mental health disorders and symptoms, as well as suicide.

A person may be diagnosed with depression if they feel some of the following signs and symptoms every day for at least two weeks; irritability, feelings of hopelessness, persistent sad or anxious mood, decreased energy or fatigue, difficulty sleeping or waking up early, appetite or weight changes, thoughts of suicide and more.

Through our One Mind Rising Star Awards grant program and other funding support channels, One Mind has supported the following scientists in their important and influential depression focused research:

1 World Health Organization