Major depression is one of the most common mental disorders, affecting more than 264 million people worldwide.1 Although it is common for people to have short-term mood fluctuations, major depression with moderate to severe intensity can become a serious life altering condition. The burden of depression is on the rise.

Depression does not have one single cause but several biological, psychological and environmental risk factors. For youth and teens, depression is a risk factor for developing other mental health disorders and symptoms, as well as suicide.

A person may be diagnosed with depression if they feel some of the following signs and symptoms every day for at least two weeks; irritability, feelings of hopelessness, persistent sad or anxious mood, decreased energy or fatigue, difficulty sleeping or waking up early, appetite or weight changes, thoughts of suicide and more.

Through our One Mind Rising Star Awards grant program and other funding support channels, One Mind has supported the following scientists in their important and influential depression focused research:

1 World Health Organization


Olivier Berton, Ph.D.
Evaluating How to Use Stress-Governing Proteins to Diagnose, Treat or Prevent Affective Disorders
Program Director
NIDA/BRAIN Initiative
2010 Rising Star Awardee
Stephanie Dulawa, Ph.D.
Developing Faster-Onset Antidepressants
Associate Professor of Psychiatry
University of California, San Diego
2014 Rising Star Awardee
Erin Dunn, ScD, MPH
Severe Exposure, DNA Methylation, and Risk for Depression: In Search of Sensitive Periods in Development
Assistant Professor of Psychiatry
2018 Rising Star Awardee
Kafui Dzirasa, M.D., Ph.D.
Closed Loop Actuators to Repair Brain Circuit Dysfunction
Assistant Professor of Psychiatry and Behavioral Sciences
Duke University
2013 Rising Star Awardee
Ming-Hu Han, Ph.D.
Understanding Stress Resilience to Remedy Depression
Associate Professor of Pharmacology and Systems Therapeutics
Mount Sinai
2011 Rising Star Awardee
Mazen Kheirbek, Ph.D.
Illuminating Circuit Based Targets for Treatment of Depression
Assistant Professor of Psychiatry & Neuroscience
University of California, San Francisco
2016 Rising Star Awardee
Stephan Lammel, Ph.D.
Decoding Multiple Dimensions of Dopamine Signaling for Impulse Control
Assistant Professor of Neurobiology
University of California, Berkeley
2019 Rising Star Awardee
Francis Lee, Ph.D.
Investigating the Role of a Growth Factor Deficiency in Affective Disorders
Chair of Department of Psychiatry
Weill Cornell Medical College
2009 Rising Star Awardee
Laura Lewis, Ph.D.
Identifying Intersecting Network Dynamics Underlying Sleep and Mood in Depression
Assistant Professor of Biomedical Engineering
Boston University
2019 Rising Star Awardee
Conor Liston, M.D., Ph.D.
Neurobiologically Distinguishing Depression Subtypes
Assistant Professor of Neuroscience and Psychiatry
Weill Cornell Medical College
2015 Rising Star Awardee
Mary Kay Lobo, Ph.D.
Stabilizing Neuronal Architecture for Depression Therapeutics
Assistant Professor of Anatomy and Neurobiology
University of Maryland
2016 Rising Star Awardee
Ian Maze, Ph.D.
Validation of histone serotonylation as a predictive biomarker for stress susceptibility, major depressive disorder and antidepressant efficacy
Assistant Professor, Departments of Neuroscience and Pharmacological Sciences
Icahn School of Medicine at Mount Sinai
2017 Rising Star Awardee
Katie McLaughlin, Ph.D.
Understanding How Stress Causes Anxiety and Depression in Youth
Associate Professor of Psychology
2015 Rising Star Awardee
Lisa Monteggia, Ph.D.
Reverse-Engineering the Rapid Antidepressant Effect of Ketamine
Barlow Family Director of the Vanderbilt Brain Institute
2011 Rising Star Awardee
Scott Russo, Ph.D.
Investigating the Anti-Depressant Efficacy of Anti-Inflammatory Medications
Assistant Professor of Neuroscience
Mount Sinai
2012 Rising Star Awardee
Alik Widge, M.D., Ph.D.
Reverse Translational Circuit Dissection and Remediation of Mental Inflexibility
Assistant Professor of Psychiatry
University of Minnesota
2017 Rising Star Awardee